Role of p38γ - NFATc4 - IL17A Pathway As a Potential Therapeutic Target in Cutaneous T Cell Lymphoma
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چکیده
منابع مشابه
Notch1 as a potential therapeutic target in cutaneous T-cell lymphoma.
Deregulation of Notch signaling has been linked to the development of T-cell leukemias and several solid malignancies. Yet, it is unknown whether Notch signaling is involved in the pathogenesis of mycosis fungoides and Sézary syndrome, the most common subtypes of cutaneous T-cell lymphoma. By immunohistochemistry of 40 biopsies taken from skin lesions of mycosis fungoides and Sézary syndrome, w...
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Background and aim: Adult T cell leukemia/lymphoma (ATLL) is an aggresive malignancy which may occur in human T lymphotropic virus1(HTLV1) infected persons. HTLV1 is endemic in Khorasan with prevalence of 2.3% in general population. Since specific cutaneous manifestations of lymphoma may occur in a significant number of patients, we studied ATLL patients in Mashhad.Mate...
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Classification of cutaneous T-cell lymphomas (CTCL), encompass several subtypes that vary considerably in terms of clinical presentation and prognosis [1]. When mycosis fungoides (MF) is a slowly progressing skin invasion by clonally derived malignant CD4+ T-lymphocytes, Sézary syndrome (SS) is a more aggressive form characterized by the presence of clonal T-cell populations in the skin, lymph ...
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ژورنال
عنوان ژورنال: Blood
سال: 2016
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v128.22.2725.2725